Mycobacterium tuberculosis shikimate kinase inhibitory activity of a glycodidepside mixture from Cosmospora sp. BioMCC-f.T-7332
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ID: 320983
2026
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Abstract
Screening of Indonesian microbial extracts identified Cosmospora sp. BioMCC-f.T-7332 as a source of Mycobacterium tuberculosis shikimate kinase (MtSK) inhibitors. A mixture of alkylated glycodidepsides TPI-1 and TPI-2 was obtained as the inhibitor (IC50 = 1.5 µg/mL) with low cytotoxicity. Although improvements in cell permeability are necessary, didepsides may serve as starting points for the development of antitubercular agents targeting MtSK.
| Reference Key |
openalex_W7168270611
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| Authors | Eka Siska, Novriyandi Hanif, Gustini Syahbirin, Erwahyuni Endang Prabandari, Danang Waluyo, Titin Ariyani, Amila Pramisandi, Diana Dewi, Arif Nurkanto, Kin-ichi Oyama, Mihoko Mori, Tomoyoshi Nozaki |
| Journal | bioscience biotechnology and biochemistry |
| Year | 2026 |
| DOI |
10.1093/bbb/zbag103
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| URL | |
| Keywords | Keywords not found |
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