Examining the role of dipeptidyl peptidase IV (DPPIV) in psoriatic disease
Clicks: 1
ID: 320875
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
0.0
/100
1 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
Ranked #174 of 198 articles by views in Lara D. Veeken
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 198 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
OBJECTIVES: Chemokine CXCL10 plays an important role in Psoriatic Arthritis (PsA), an inflammatory arthritis associated with psoriasis. CXCL10 is post-translationally regulated by dipeptidyl peptidase-4 (DPPIV). The objectives of this study were to measure levels of DPPIV, CXCL10 and DPPIV enzyme activity (EA) in patients with PsA, psoriasis without arthritis (PsC), osteoarthritis (OA) and healthy controls (HC), and in PsA patients before and after methotrexate (MTX) treatment initiation. METHODS: Serum samples from 80 PsA, 80 PsC, 40 HC, and 40 patients before and after 24 weeks of MTX treatment. Synovial fluid (SF) and matched serum were collected from 14 PsA and 14 sex- matched OA patients. Levels of DPPIV, CXCL10, were quantified using ELISA, DPPIV EA was measured using a luminescent protease assay. RESULTS: Patients with PsA had higher DPPIV levels than PsC, whereas HC had the highest level compared with both. Significant increase in DPPIV levels was observed in PsA patients after MTX treatment, whereas CXCL10 levels decreased significantly. DPPIV levels were negatively correlated with CXCL10 levels after MTX treatment (r=-0.27, p= 0.02). DPPIV levels were significantly higher in SF of PsA compared with OA patients. Higher DPPIV levels were detected in SF compared with serum samples of PsA patients. CXCL10 concentration in synovial fluid displayed similar patterns to DPPIV. CONCLUSION: Our exploratory findings suggest that DPPIV synovial fluid levels may be an important indicator of joint inflammation in PsA patients. In PsA patients, DPPIV may be associated with MTX response. CXCL10 may be regulated post translationally by DPPIV.
| Reference Key |
openalex_W7168198759
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Kirubel Goliad, Omar Fernando Cruz-Correa, Darshini Ganatra, Rohan Machhar, Dafna D. Gladman |
| Journal | Lara D. Veeken |
| Year | 2026 |
| DOI |
10.1093/rheumatology/keag360
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.