The New Vaccine Surveillance Network: 25 years of active, population-based surveillance for pediatric infectious diseases in the United States

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ID: 320870
2026
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Abstract
BACKGROUND: In 1999, the Centers for Disease Control and Prevention (CDC) established the New Vaccine Surveillance Network (NVSN) as a multi-site pediatric infectious diseases active surveillance system. METHODS: NVSN prospectively collects population-based clinical, epidemiologic, and laboratory information on children who seek medical care at hospitals, emergency departments, urgent care centers, and outpatient clinics with symptoms of acute respiratory infections (ARI) and acute gastroenteritis (AGE) in the United States. RESULTS: These efforts have clearly established the significant burden of both ARI and AGE in US children, demonstrated the effectiveness of licensed pediatric vaccines, and helped guide their use. The surveillance platform also measures the real-world impact of preventive measures intended to avoid or ameliorate adverse child health outcomes within the US healthcare system. Furthermore, NVSN provides a platform for detecting and evaluating emerging infections (e.g. enterovirus D-68, SARS-CoV-2) and unexpected sequelae in children. CONCLUSIONS: For 25 years NVSN has provided an evidence-based foundation for pediatric infectious disease policy decision-making through objective, empirical data. Sustained investment in disease surveillance guides the scientific principles and public health practices that prevent suffering and premature death, prepares us for new and existent pathogen threats, and enables wise economic decisions that improve the health of Americans.
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Authors Daniel C. Payne, Geoffrey A. Weinberg, Natasha B Halasa, Janet A. Englund, J A Boom, Rangaraj Selvarangan, Marian G. Michaels, John V. Williams, Leila C. Sahni, Eileen J Klein, Christopher J. Harrison, Jennifer E. Schuster, Elizabeth P. Schlaudecker, M GRIFFIN, Kathryn M Edwards, Sara A. Mirza, Heidi L. Moline, Fatimah S Dawood, Umesh D Parashar, Mary Allen Staat, P Szilagyi, NVSN Collaborators, Christina Albertin, James Alexander, Larry J Anderson, Vasanthi Avadhanula, Parvin Azimi, Carol Baker, Julia M. Baker, Dithi Banerjee, Eddie Bartlett, David I Bernstein, Michael Bowen, Carolyn B. Bridges, Hannah Browne, Allison R Burrell, Angela Campbell, Jennifer R Cannon, James D Chappell, Chhabra Pc, Benjamin R Clopper, Veronica Constantini, Margaret M. Cortese, M J Coughlin, Stephanie Donauer, John R. Dunn, Sascha Ellington, Shane Embury, Monica Epperson, Dean Erdman, Matthew D. Esona, Gerry Fairbrother, Alicia Fry, Wende Fregoe, Jon R. Gentsch, Susan I Gerber, Roger I. Glass, Leah Goldstein, Oscar G. Gómez‐Duarte, N Gregoricus, Aron J. Hall, Caroline B Hall, Olla Hamdan, Ferdaus Hassan, Amber Haynes, Robert W. Hickey, Annika Hofstetter, Sharon Humiston, Marika K. Iwane, Baoming Jiang, Samantha H. Johnston, Gaurav Kwatra, Kristen Lacombe, Gayle Langley, Teresa Lin, Joanna Lively, G T Loftus, Adriana Lopez, Benjamin A. Lopman, Kevin Ma, Rendi McHenry, Meredith McMorrow, Claire P. Mattison, Monica McNeal, Claire Midgley, Mary E Moffatt, Ardythe L. Morrow, Flor Munoz, Samar Musa, Kenny Nguyen, Constance Ogokeh, Walter A. Orenstein, Ismael R. Ortega‐Sanchez, Manish M Patel, Chastity Perkins, Alexi Piasecki, Pedro (Tony) A Piedra, Katherine A. Poehling, Mila Prill, Christina Quigley
Journal Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Year 2026
DOI
10.1093/cid/ciag434
URL
https://doi.org/10.1093/cid/ciag434
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