Bullous pemphigoid needs two axes, not one: refining the actionable inflammatory endotype
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ID: 320848
2026
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Abstract
Commenting on Cao et al., we argue that their inflammatory phenotype of bullous pemphigoid is better characterised as IL-13/alarmin-driven than eosinophil-defined—favouring IL-4Rα blockade over eosinophil-directed therapy—and that the reciprocal phenotype should not be assumed low-risk. We therefore propose a complementary autoantibody/complement axis alongside the type 2 axis, with prospective multicentre calibration linking both to differential treatment response as the necessary next step.
| Reference Key |
openalex_W7168158415
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|---|---|
| Authors | Menglu Zhang, Biao Song |
| Journal | the british journal of dermatology |
| Year | 2026 |
| DOI |
10.1093/bjd/ljag278
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| URL | |
| Keywords | Keywords not found |
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