damidBind: an R/Bioconductor package for differential DamID analysis and data exploration

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ID: 320805
2026
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Abstract
SUMMARY: DamID, and its cell-type specific adaptations, including Targeted DamID (TaDa) and Chromatin Accessibility TaDa (CATaDa), are now widely-adopted as techniques for the genome-wide profiling of DNA binding proteins. Despite this popularity, no dedicated software solution exists for identifying differentially bound or accessible loci, or differentially transcribed genes, between cell types using DamID. The R/Bioconductor package damidBind provides these functions, allowing an end-user to move from processed binding profiles to identifying differentially-bound loci in a reproducible, statistically appropriate and straightforward workflow. AVAILABILITY AND IMPLEMENTATION: damidBind is an open-source R/Bioconductor package and freely available from Bioconductor at https://bioconductor.org/packages/damidBind/, and from GitHub at https://github.com/marshall-lab/damidBind. It is released under the GPLv3 licence.
Reference Key
openalex_W7168129392 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Owen J Marshal
Journal BMC Bioinformatics
Year 2026
DOI
10.1093/bioinformatics/btag512
URL
https://doi.org/10.1093/bioinformatics/btag512
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