Urinary Metabolic Age from High-Resolution NMR Reveals Longitudinal Aging Patterns

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ID: 320800
2026
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Abstract
Biological age captures inter-individual heterogeneity in aging process arising from genetic and environmental influences. Metabolites, as the end-products of metabolism, integrate these factors and are therefore well suited for biological age estimation. Urinary metabolomics, in particular, provides a non-invasive and information-rich matrix for assessing systemic metabolic states. We applied different machine learning techniques to develop a biological age score from high-resolution 1H nuclear magnetic resonance (NMR) metabolites measured in urine samples from a large population-based cohort. The derived metabolic age score was applied to evaluate longitudinal trajectories over more than a decade. Cross-sectional associations with age-related clinical phenotypes were examined, and prospective analyses assessed associations with incident diseases and all-cause mortality. Metabolic age progression over time varied between individuals, underscoring inter-individual heterogeneity in metabolic aging. In cross-sectional analyses, the metabolic age score showed biologically plausible associations with a range of age-related clinical phenotypes. Furthermore, metabolic age was predictive of multiple diseases and all-cause mortality independent of chronological age. Our findings highlight the utility of urinary metabolomics as a robust, non-invasive approach for biological age assessment. The characterization of long-term metabolic age trajectories provides novel insight into inter-individual differences in aging and establishes urinary metabolic age as a promising tool for risk stratification and aging research.
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Authors Karen Friederike Gauß, N Friedrich, Ann‐Kristin Henning, Johannes Hertel, Hans Jörgen Grabe, Henry Völzke, Nauck Ma, Astrid Petersmann
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Journal the journals of gerontology series a, biological sciences and medical sciences
Year 2026
DOI
10.1093/gerona/glag180
URL
https://doi.org/10.1093/gerona/glag180
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