Higher habitual protein intake is not linked to decline of iohexol-measured GFR in adults ≥40 years
Clicks: 22
ID: 320654
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
7.6
/100
22 views
8 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #16 of 150 articles by views in clinical kidney journal
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 150 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Abstract Background High habitual dietary protein intake may increase glomerular workload and contribute to hyperfiltration, but the long-term renal effects in individuals without chronic kidney disease (CKD) remain debated. Prior population studies have relied on estimated glomerular filtration rate (eGFR), which may be biased by non-GFR determinants. We examined whether higher protein intake is associated with decline in kidney function using repeated measurements of iohexol-measured GFR (mGFR). Methods We analysed data from the Renal Iohexol Clearance Survey (RENIS), a population-based cohort with repeated mGFR measurements over follow-up (n=1,324). Baseline protein intake was estimated using a validated food-frequency questionnaire. Associations of protein intake with GFR decline rate, accelerated GFR decline (top 10% with the steepest annual reductions), and incident incident mGFR <60 mL/min/1.73 m² were assessed using linear mixed models, logistic regression, and interval-censored Cox regression. Results Mean age was 64 years, 50% were women, and mean baseline mGFR was 89 mL/min/1.73 m². Median follow-up was 10 years. Mean reported protein intake was 1.2 ± 0.5 g/kg/day, with the lowest quartile consuming <0.9 g/kg/day and the highest ≥1.4 g/kg/day. Protein intake was not associated with mGFR decline (−0.01 mL/min/1.73 m² per year [95% CI −0.04 to 0.02] per 0.1 g/kg/day higher protein intake). Protein intake was not associated with accelerated GFR decline or incident mGFR <60 mL/min/1.73 m². Conclusions Among middle-aged and older adults in the general population, higher estimated habitual protein intake was not associated with mGFR decline.
| Reference Key |
openalex_W7168017663
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Ludvig Balteskard Rinde, Laila A Hopstock, Marie Wasmuth Lundblad, Nikoline Balteskard Rinde, Karl-Marius Brobak, Jon Viljar Norvik, Inger-Therese Enoksen, Marit D Solbu, Ole-Martin Fuskevåg, Juan Jesús Carrero, Monica Hauger Carlsen, Björn O. Eriksen, Toralf Melsom |
| Journal | clinical kidney journal |
| Year | 2026 |
| DOI |
10.1093/ckj/sfag235
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.