Lactobacillus plantarum protects broilers against Salmonella Typhimurium infection via modulating TLR4/MyD88/NF-κB signaling pathway and gut microbiota

Clicks: 2
ID: 320495
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal

Ranked #95 of 171 articles by views in Journal of applied microbiology

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 171 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Aims Salmonella Typhimurium (ST) infection in broilers threatens food security and public health, and antibiotic overuse causes serious side effects. This study aimed to evaluate the protective effects and mechanism of Lactobacillus plantarum (LW) isolated from Tibetan chickens against ST infection in broilers. Methods and Results Eighty 1-day-old Arbor Acres broilers were randomly divided into four groups (n = 20 per group): control (CC), LW supplementation (LW), ST infection (ST), and ST + LW treatment (PR). Broilers in LW and PR groups were orally administered 1 × 10⁸ CFU mL−1 LW from day 4 to day 21, and those in ST and PR groups were challenged with 1 × 10⁸ CFU mL−1 ST from day 15 to day 18. Results showed that LW significantly alleviated ST-induced growth retardation, oxidative stress and intestinal histological injury. Meanwhile, LW inhibited NF-κB pathway to reduce intestinal inflammation, upregulated tight junction proteins to enhance intestinal barrier function, increased the abundance of Lactobacillus and Bacilli to optimize gut microbiota, and maintained taurine levels to regulate taurine and hypotaurine metabolism. Conclusions LW effectively protects broilers from ST infection via regulating intestinal immunity, barrier function, gut microbiota and metabolism. LW can be used as a safe and effective probiotic to prevent ST infection in poultry, thus reducing food safety risks and ensuring public health.
Reference Key
openalex_W7167897037 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Lei Wang, A Min, Mei‐Yan Xu, Xi Zhang, Fazul Nabi, Bo Li, Jiakui Li
Journal Journal of applied microbiology
Year 2026
DOI
10.1093/jambio/lxag163
URL
https://doi.org/10.1093/jambio/lxag163
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.