Dehydro-metabolites of siphonaxanthin predominate in skin tissues and retain biological activity in keratinocytes
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ID: 320161
2026
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Abstract
Siphonaxanthin attenuated ultraviolet B (UVB)-induced cytokine expression in HaCaT cells and primary normal human epidermal keratinocytes. After oral intake of siphonaxanthin in mice, siphonaxanthin and its dehydro-metabolites were detected in plasma and skin-related tissues, with dehydro-metabolites predominating. The metabolites modulated UVB-induced responses as well as siphonaxanthin itself, suggesting that the metabolic conversion does not abolish the activity.
| Reference Key |
openalex_W7167575229
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|---|---|
| Authors | Yuki Manabe, Natsuki Hashimoto, Chika Nakayama, Tomoaki Nitta, Tatsuya Sugawara |
| Journal | bioscience biotechnology and biochemistry |
| Year | 2026 |
| DOI |
10.1093/bbb/zbag100
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| URL | |
| Keywords | Keywords not found |
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