Dehydro-metabolites of siphonaxanthin predominate in skin tissues and retain biological activity in keratinocytes

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ID: 320161
2026
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Abstract
Siphonaxanthin attenuated ultraviolet B (UVB)-induced cytokine expression in HaCaT cells and primary normal human epidermal keratinocytes. After oral intake of siphonaxanthin in mice, siphonaxanthin and its dehydro-metabolites were detected in plasma and skin-related tissues, with dehydro-metabolites predominating. The metabolites modulated UVB-induced responses as well as siphonaxanthin itself, suggesting that the metabolic conversion does not abolish the activity.
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Authors Yuki Manabe, Natsuki Hashimoto, Chika Nakayama, Tomoaki Nitta, Tatsuya Sugawara
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Journal bioscience biotechnology and biochemistry
Year 2026
DOI
10.1093/bbb/zbag100
URL
https://doi.org/10.1093/bbb/zbag100
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