Correlation of vascular enhancement on MRI and clinical manifestations in patients with giant cell arteritis

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ID: 319832
2026
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Abstract
Abstract Objectives Giant cell arteritis (GCA) has diverse cranial manifestations, and cranial vessel MRI (cvMRI) can assess multiple arteries simultaneously. We aimed to determine whether vessel-specific enhancement on cvMRI correlates with clinical manifestations and diagnosis in GCA. Methods We conducted a retrospective cohort study of patients who underwent cvMRI for suspected GCA at a single academic center. We assessed associations between vessel wall enhancement on cvMRI and anatomically expected GCA symptoms. We used univariate and multivariable logistic regression adjusting for age, sex, and glucocorticoid exposure to assess the relationship between vessel abnormalities and a diagnosis of GCA. Results Among 439 patients, 153 (34.9%) were diagnosed with GCA. Median time (quartile 1[Q1]-quartile 3[Q3]) from glucocorticoid initiation to cvMRI was 11.5 days (Q1-Q3: 5.8–207.2). Maxillary and ophthalmic artery involvement were specific but insensitive for jaw claudication and vision loss, respectively (Specificity 87.1%, 95% confidence interval [CI] 80.3–93.9 and 72.6%, 95% CI 61.5–83.7; Sensitivity 40.0%, 95% CI 26.5–51.4 and 43.3%, 95% CI 33.1–53.6, respectively). Headache showed no association with specific vessels. Any arterial enhancement was associated with GCA in univariate analysis, but only temporal artery involvement was predictive in multivariable analysis (OR 5.20, 95% CI: 1.65–16.88), particularly when bilateral (OR 9.82, 95% CI: 2.82–38.32). Conclusion Temporal artery enhancement remains the strongest imaging correlate for a diagnosis of GCA. Vessel-specific enhancement on cvMRI correlates with vision loss and jaw claudication but not headache. cvMRI may aid diagnosis in diagnostically uncertain cases, even after glucocorticoid initiation.
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Authors N S Rai, Azin Khosavirad, Lawrence Mbuagbaw, Rennie L. Rhee, Ryan Rebello, N Khalidi, Mats Junek
Journal Rheumatology Advances in Practice
Year 2026
DOI
10.1093/rap/rkag060
URL
https://doi.org/10.1093/rap/rkag060
Keywords Keywords not found

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