Exercise Promotes Glutamate Transporter-Mediated Glutamate Uptake in the Striatum to Regulate MSN Plasticity and Alleviate Behavioral and Functional Impairments in PD Rats
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ID: 319749
2026
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Abstract
This study investigated whether exercise ameliorates behavioral deficits in a rat model of Parkinson's disease (PD) by regulating medium spiny neuron (MSN) plasticity via striatal astrocytic excitatory amino acid transporters (EAATs). The PD model was induced by 6-hydroxydopamine (6-OHDA) and confirmed by apomorphine rotation. Exercised rats underwent 4 weeks of treadmill training. We assessed motor function using beam walking and cylinder tests. Striatal pathology was evaluated via tyrosine hydroxylase (TH) immunohistochemistry, glutamate (Glu) ELISA, c-Fos tracing, Western blotting for GLAST/GLT-1/NMDAR, Golgi staining for dendritic spines, and in vivo local field potential (LFP) recording. Compared to controls, PD rats exhibited motor impairment, dopamine depletion, increased striatal Glu levels, NMDAR expression, and beta-oscillations, alongside reduced EAAT expression and spine density. Exercise significantly reversed these abnormalities and improved behavior. Notably, pharmacological blockade of EAATs in exercised rats completely abolished these neuroprotective effects, reinstating the PD phenotype. These findings indicate that treadmill exercise upregulates striatal EAATs (GLAST/GLT-1), enhances Glu uptake, reduces extracellular Glu, and suppresses NMDAR overactivation and beta-oscillations. This restoration of Glu homeostasis promotes MSN morphological and functional remodeling, serving as a critical mechanism for exercise-induced behavioral improvement in PD.
| Reference Key |
openalex_W7167498103
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|---|---|
| Authors | Ping Chen, Wen-Hui Zhou, Guoyu Li, Quan Yang, Bing Liu, Xin-Yu Yi, Yuan Zeng |
| Journal | the journals of gerontology series a, biological sciences and medical sciences |
| Year | 2026 |
| DOI |
10.1093/gerona/glag173
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| URL | |
| Keywords | Keywords not found |
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