A Delphi survey of patients and clinicians on a unified and stratified approach to managing GCA–PMR spectrum disease
Clicks: 1
ID: 319611
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
0.0
/100
1 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
Ranked #186 of 202 articles by views in Lara D. Veeken
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 202 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
OBJECTIVES: This Delphi survey, involving patients, primary and secondary care clinicians, and experts was conducted to evaluate the giant cell arteritis (GCA), polymyalgia rheumatica (PMR) Spectrum Disease (GPSD) and its implications. The GPSD concept proposes a unified framework for diagnosis and treatment of overlapping conditions including cranial and extracranial GCA and PMR. The survey included two rounds and addressed six propositions covering disease nomenclature, phenotypes, imaging, stratification, and clinical impact. METHODS: Round 1 achieved consensus across all propositions, with over 75% agreement and several items exceeding 90%. Key areas of agreement included recognition of GPSD (92%), the role of imaging in diagnosis and stratification (100%), and the need for multilevel assessment (100%). Round 2 refined and clarified questions, further strengthening consensus, with some items reaching 100% agreement. Internal consistency analysis confirmed the survey's reliability and validity for future use. RESULTS: The GPSD model promotes comprehensive evaluation of all phenotypes regardless of initial presentation. It advocates early specialist involvement, personalized treatment strategies, and improved diagnostic tools. Imaging modalities such as ultrasound and PET are essential for detecting subclinical disease, excluding alternative diagnoses, and guiding management, especially when symptoms are ambiguous. Stratified care in PMR addresses diagnostic uncertainty and highlights emerging therapies like cytokine blockade. CONCLUSION: The model supports prospective studies using baseline imaging and stratified treatment arms to monitor disease control and long-term outcomes. By unifying fragmented care pathways and promoting a spectrum-based approach, GPSD has the potential to improve patient outcomes, reduce misdiagnosis, and guide more effective therapeutic strategies across related inflammatory conditions.
| Reference Key |
openalex_W7167248433
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Daniel Robbins, M. Khurshid, L Greenberg Neil, Jean Andow, Madeline Whitlock, Patricia Fedi, Alessandro Tomelleri, Kornelis S M van der Geest, Alwin Sebastian, Aby Valliatu, Deepak Kumar, Christian Dejaco, Barbara Pierscionek, Masayoshi Harigai, Bhaskar Dasgupta |
| Journal | Lara D. Veeken |
| Year | 2026 |
| DOI |
10.1093/rheumatology/keag337
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.