Pulsed Field or Cryoballoon Ablation for Paroxysmal Atrial Fibrillation – insights from acute and chronic electroanatomic remapping in the randomized SINGLE-SHOT CHAMPION trial
Clicks: 1
ID: 319582
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
0.0
/100
1 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
Ranked #77 of 83 articles by views in EP Europace
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
BACKGROUND AND AIMS: The SINGLE SHOT CHAMPION multicenter trial compared the effectiveness of pulsed-field ablation (PFA) and cryoballoon ablation (CBA) for pulmonary vein isolation (PVI) in patients with paroxysmal atrial fibrillation (AF). In a prespecified sub-study, post-ablation three-dimensional electroanatomic mapping (3D-EAM) was performed, and repeat-procedure mapping data were analyzed. METHODS: Patients were randomized 1:1 to fluoroscopy-guided PVI with PFA or CBA. The first 25 patients in each group underwent high-density 3D-EAM immediately after ablation. Acute PV isolation and lesion geometry were assessed using bipolar voltage thresholds of 0.1 mV, 0.2 mV, and 0.5 mV. Lesion durability was evaluated at clinically indicated repeat ablation. RESULTS: In acute post-ablation mapping, residual PV conduction was seen in 4/25 (16%) CBA patients and 0/25 PFA patients (P=0.11). Inadvertent posterior wall conduction block occurred after PFA in 3 (12%) patients with small atria (mean LA volume 30.7 ml). PFA created larger left-sided lesions (antral area <0.5 mV: 5.7 mm2 [IQR 4.6-6.5] vs 4.4 mm2 [IQR 2.5-5.5], P=0.026) and narrower posterior wall channels (14.0 mm [IQR 10.5-20.6] vs. 24.0 mm [IQR 19.1-26.9], P<0.001), indicating wide-antral isolation. At redo (n=48), durable PVI was seen in 4/26 (15%) PFA and 3/22 (14%) CBA patients and in 63/102 (62%) veins after PFA and 52/82 (63%) after CBA (P=0.88). CONCLUSION: Fluoroscopy- and electrocardiogram-guided PVI can result in incomplete PV isolation after CBA or unintentional posterior wall block after PFA. In the acute mapping cohort, PFA yielded broader left-sided lesions than CBA; in a separate redo cohort, chronic PV durability was similar for both modalities.
| Reference Key |
openalex_W7167278065
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Thomas Kueffer, Sven Knecht, E Ayadi, David Spreen, Salik ur Rehman Iqbal, Gregor Thalmann, Patrick Badertscher, Jens Maurhofer, Philipp Krisai, Nikola Kozhuharov, Peter Jüni, Corinne Jufer, Helge Servatius, Hildegard Tanner, Michael Kühne, Laurent Roten, Tobias Reichlin, Christian Sticherling |
| Journal | EP Europace |
| Year | 2026 |
| DOI |
10.1093/europace/euag167
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.