Cardiac involvement in Behçet’s syndrome: findings from a clinically driven cardiological evaluation
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ID: 319491
2026
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Abstract
Abstract Objectives To characterize prevalence, patterns, and clinical correlates of cardiac involvement in a cohort of patients with Behçet’s syndrome (BS) undergoing clinically-driven cardiological assessment. Methods This retrospective study included adult patients with BS, followed at a tertiary referral center (Florence, Italy), who underwent clinically-driven cardiological evaluation. Clinical, demographic, and therapeutic characteristics were compared in patients with and without evidence of cardiac involvement. Timing, type of cardiac involvement, disease activity, cardiovascular risk factors, and treatments were analyzed. Results Among 312 patients with BS, 90 underwent cardiological assessment and 49 had confirmed cardiac involvement. Arrhythmias were the most frequent manifestation (n = 15), followed by pericarditis (n = 12) and ischemic heart disease (n = 8). Cardiac involvement occurred a median of 6.1 (2.5—8.7) years after BS diagnosis, although in a proportion of patients they preceded or coincided with diagnosis. Most patients had active systemic disease at the time of the cardiac involvement (93.9%), and were receiving immunosuppressant treatment (84%). Over 80% had at least one traditional cardiovascular risk factor, yet <40% were receiving cardiovascular primary prevention therapy before the first event. Male patients more frequently experienced ischemic manifestations, while arrhythmias were more common in females. No cardiac-related deaths were observed. Conclusion Cardiac involvement in BS is more common than traditionally reported when actively investigated. Cardiac involvement frequently occurs during active disease and in patients with a high burden of cardiovascular risk factors but suboptimal preventive therapy. These findings support the need for integrated cardio-rheumatologic management in BS.
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| Authors | Alessandra Bettiol, Federica Bello, Ruggero Mazzotta, Irene Mattioli, Giacomo Bagni, Edoardo Biancalana, Maria Canfora, Mariapaola Lisi, Danilo Malandrino, Miki Palmerini, Maurizio Pieroni, Maria Romanelli, Maria Letizia Urban, Savino Sciascia, Domenico Prisco, Elena Silvestri, Iacopo Olivotto, Giacomo Emmi |
| Journal | Lara D. Veeken |
| Year | 2026 |
| DOI |
10.1093/rheumatology/keag292
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| URL | |
| Keywords | Keywords not found |
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