Blood cytotoxic natural killer-like CD8 + CD94+ T cells migrate to the brain and predict multiple sclerosis severity

Clicks: 1
ID: 319371
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal

Ranked #372 of 375 articles by views in Brain research

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 375 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Memory CD8+ T cells are central to multiple sclerosis (MS) and undergo clonal expansion, but disease-associated states remain incompletely defined. By single-cell profiling of circulating memory CD8+ T cells from patients with relapsing-remitting MS, healthy volunteers, and neuroinflammatory controls, we identified an MS-associated cytotoxic subset with NK-like features. These cells increase around relapse activity and belong to an oligoclonal reservoir. In an independent cohort sampled at the first clinical event, an elevated frequency of NK-like CD8+ T cells predicted an aggressive MS course two years later and was associated with a migratory/inflammatory program. Bulk and single-cell RNA-seq confirmed the NK-like transcriptional signature, and functional assays demonstrated TCR-independent cytotoxicity. Immunostaining and spatial transcriptomics revealed enrichment of these cells in MS lesions and a spatial association with macrophages/microglia. Together, our results identify a cytotoxic NK-like CD8+ T-cell subset that links peripheral inflammation to CNS lesions and may serve as an early biomarker of MS severity.
Reference Key
openalex_W7166731884 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Emilie Dugast, Sita Shah, Isabel Vogel, Amandine Loret, Céline Monvoisin, Alexandra Garcia, Cynthia Fourgeux, Victor Gourain, Léo Boussamet, Roberta Amoriello, Jean-Benoît Le Luduec, Serge Nataf, Marylène Jacq-Foucher, Mélinda Moyon, Fabienne Le Frère, Sandrine Wiertlewski, Clara Ballerini, Karin Tarte, Eric Thouvenot, Hanane Agherbi, Romain Casey, Sandra Vukusic, Aurélie Ruet, E Le Page, Pierre Labauge, Guillaume Mathey, Catarina Raposo, Jérémie Poschmann, Amédée Renand, Arnaud Nicot, Laure Michel, Pierre‐Antoine Gourraud, Laureline Berthelot, D. Laplaud
Journal Brain research
Year 2026
DOI
10.1093/brain/awag227
URL
https://doi.org/10.1093/brain/awag227
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.