Low Post-Treatment Recurrence After a Shortened All-oral Regimen for Pulmonary Rifampicin- or Multidrug-Resistant Tuberculosis in Individuals without Prior Second-Line Drug Exposure in Kazakhstan

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ID: 319237
2026
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Ranked #522 of 531 articles by views in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Abstract
We conducted a prospective cohort study of adults with pulmonary MDR/RR-TB in Kazakhstan treated with one of three all-oral, five-drug regimens. Individuals were followed microbiologically and clinically for up to 12 months post-treatment. Of 578 with favorable end-of-treatment outcomes, we observed only one incident case of recurrent TB (0.2%, 95%CI: 0.0-1.0%), suggesting excellent regimen durability under programmatic conditions.
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openalex_W7166870389 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Edmund Shen, Yerkebulan Algozhin, Letizia Trevisi, Allison LaHood, Elena Algozhina, Nataliya Arlyapova, Kwonjune J. Seung, Carole D. Mitnick, Michael Rich, Molly F. Franke, Makhmujan Rashitov
Journal Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Year 2026
DOI
10.1093/cid/ciag391
URL
https://doi.org/10.1093/cid/ciag391
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