10-Year Trends in Attributable and Contributable Mortality of Culture-Positive Invasive Aspergillosis in Patients with Hematologic Malignancies: Have We Reached the “Ceiling Efficacy Effect” of Modern Antifungals?

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ID: 319108
2026
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Ranked #499 of 532 articles by views in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Abstract
Abstract Given competing death causalities among hematological malignancy patients with invasive aspergillosis (IA), we assessed IA-attributable, contributable, and all-cause mortalities in patients with culture-confirmed IA. Although attributable mortality decreased, contributable and all-cause mortalities remained high. Our data suggest that improving survival would require host augmentation, in addition to improved antifungals.
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Authors Ariel D. Szvalb, Sebastian Wurster, Takahiro Matsuo, Teny M. John, Adam G. Stewart, Sung‐Yeon Cho, Yan Jiang, Dimitrios P. Kontoyiannis
Journal Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Year 2026
DOI
10.1093/cid/ciag393
URL
https://doi.org/10.1093/cid/ciag393
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