The Type III Secretion System plasmid pPHDPT3 of Photobacterium damselae subsp. piscicida is stable in Australian isolates due to conserved non-repetitive genomic architecture

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ID: 318662
2026
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Abstract
Photobacterium damselae subsp. piscicida (Pdp) is a host-adapted primary pathogen impacting finfish aquaculture worldwide, whose virulence evolution is driven by the mobilome. The pPHDPT3 plasmid encoding a type III secretion system is critical for Pdp virulence but unstable in vitro in European and Japanese isolates. Here we show that a stable ancestral variant is conserved in Australian isolates. The elusive pPHDPT3 variant has undergone gene loss and accumulated a ∼5.5 kb quadruple direct repeat, which could explain plasmid loss via the classic dimer catastrophe scenario. In addition, we hypothesise that a 189-aa serine recombinase encoded within this repeat, and also on pPHDP10 plasmid, may act as a plasmid resolvase, with its frequent loss further exacerbating the dimer catastrophe.
Reference Key
openalex_W7165733244 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Oleksandra Rudenko, Laura Baseggio, Andrew C. Barnes
Journal FEMS microbiology letters
Year 2026
DOI
10.1093/femsle/fnag074
URL
https://doi.org/10.1093/femsle/fnag074
Keywords Keywords not found

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