Neurite Outgrowth–Promoting Furanocoumarins Isolated from Sudachi Juice in PC12 Cells
Clicks: 3
ID: 318499
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
0.6
/100
3 views
2 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #58 of 65 articles by views in bioscience biotechnology and biochemistry
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Abstract Sudachi (Citrus sudachi, a citrus fruit of the Rutaceae family) juice was found to promote neurite outgrowth in PC12 cells. Activity-guided purification of the juice led to the isolation of two furanocoumarins, byakangelicin and isopimpinellin, and a flavone, demethoxysudachitin, identifying them as neurite-outgrowth promoters for the first time. Byakangelicin and isopimpinellin showed markedly stronger neurite outgrowth–promoting activity than demethoxysudachitin, prompting a comparative evaluation of five furanocoumarins, including both isolated and related reference compounds. The results showed that the basic furanocoumarin scaffold alone is inactive, whereas substitution at either the C5 or C8 position of a furanocoumarin confers prominent activity, with dual substitution further improving activity. Among the tested compounds, byakangelicin and isopimpinellin exhibited the most potent neurite outgrowth–promoting activity. These findings identify sudachi-derived furanocoumarins as previously unrecognized neurite-outgrowth promoters and suggest their potential as neurotrophic agents for supporting cognitive function.
| Reference Key |
openalex_W7165684706
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Saki Morimoto, Takeru Koga, Saho Miyazaki, Akihiro Tai |
| Journal | bioscience biotechnology and biochemistry |
| Year | 2026 |
| DOI |
10.1093/bbb/zbag092
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.