P50 Noncoding small nucleolar RNA host genes as novel therapeutic targets in atopic dermatitis and psoriasis

Clicks: 3
ID: 318392
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #225 of 313 articles by views in the british journal of dermatology

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 313 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Introduction and aims Atopic dermatitis (AD) and psoriasis are common chronic inflammatory skin diseases characterized by abnormal keratinocyte proliferation and differentiation. Both diseases are associated with increases in different sets of cytokines, resulting in distinct but overlapping clinical features. Current therapies, such as systemic immunosuppressants, biologics and topical corticosteroids, have limitations owing to side effects and/or cost, highlighting the need for novel targeted treatments. Recent findings underscore the importance of noncoding RNAs in skin biology. MicroRNAs (miRNAs) are a type of noncoding RNAs that can modulate inflammation and keratinocyte behaviour in AD and/or psoriasis. A group of unusually highly expressed long noncoding RNAs called noncoding small nucleolar RNA host genes (ncSNHGs) can strongly stimulate keratinocytes to self-renew and inhibit their differentiation by affecting miRNA activity. In this study, we aim to investigate the potential of ncSNHGs as therapeutic targets for AD and/or psoriasis. Methods We analysed single-cell RNA sequencing datasets to assess the expression of ncSNHGs in the lesions of patients with AD and psoriasis and confirmed the expression results by in situ hybridization. We tested in silico the ability of lesions ncSNHGs to bind miRNAs that are relevant to the pathogenesis of AD and psoriasis. Results We found multiple ncSNHGs to be increased in both AD and psoriasis. Several of these lesional ncSNHGs are able to strongly affect keratinocyte proliferation and differentiation and are predicted to bind multiple miRNAs that have been implicated in AD and psoriasis. Conclusions Our preliminary results show that a subset of ncSNHGs are promising targets for the treatment of AD and psoriasis lesions. We are engineering models of AD and psoriasis using human skin equivalents challenged by different cytokine cocktails and generating primary keratinocyte lines that can be induced to downregulate epidermal ncSNHGs to further study their effectiveness and reliance on miRNA interactions.
Reference Key
openalex_W7165687987 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Matteo Vietri Rudan
Journal the british journal of dermatology
Year 2026
DOI
10.1093/bjd/ljag151.088
URL
https://doi.org/10.1093/bjd/ljag151.088
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.