Oral mucosal lesions in xeroderma pigmentosum type C in Mayotte

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ID: 318228
2026
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Abstract
Xeroderma Pigmentosum (XP) is a rare autosomal recessive disorder caused by defective DNA repair, leading to a high cancer risk. While skin and eye symptoms are well known, oral involvement is less studied. In a retrospective study of 23 XP-C patients from Mayotte sharing the same mutation, oral lesions - especially on the lips and tongue - were frequent and appeared early. All patients showed tongue abnormalities by age 12, including precancerous lesions and carcinomas. These findings reveal a distinct, early-onset pattern and stress the need for systematic oral monitoring.
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openalex_W7165563511 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Marc Dumas, Antoine Willemart, Nolwenn Lepouriel, Alice Miquel, S. Hadj‐Rabia, Antoine Bertolotti
Journal the british journal of dermatology
Year 2026
DOI
10.1093/bjd/ljag252
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