A continuous protection strategy using glycan tags to suppress aggregation of hydrophobic peptides
Clicks: 2
ID: 317889
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
0.3
/100
2 views
1 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #749 of 788 articles by views in phytochemistry letters
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 788 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Abstract We investigated combination of the glycan tag, peptide-based tag, denaturing agents, and acidic conditions to efficiently prepare highly hydrophobic peptides using E. coli expression. The hydrophilic glycan tag suppressed aggregation of long polypeptides, even when a conventional small ubiquitin-like modifier (SUMO) tag is not sufficient. Moreover, SUMO protease properly recognized and cleaved the SUMO tag in the presence of the additional glycan tag. The finding of the continuous protection strategy enabled efficient preparation of aggregation-prone peptides for semisynthesis of proteins.
| Reference Key |
openalex_W7165124031
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Yuta Maki, Youdong Yang, Junpei Abe, Ryo Okamoto, Yasuhiro Kajihara |
| Journal | phytochemistry letters |
| Year | 2026 |
| DOI |
10.1093/chemle/upag116
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.