Comparative analysis of gene expression in mammalian claustrum subdivisions

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ID: 317379
2026
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Abstract
Abstract The claustrum is a major connectivity hub for cortical circuits and has recently become a nexus for research on cognition, brain state transitions, and mood disorders. While most recent studies focus on mice, there are ongoing debates regarding the definition of rodent claustrum borders, subregions, development, and constitutive cell types. Hence, problems mount when attempting to compare the claustrum across mammals with diverging brain size and morphology. In particular, understanding the primate claustrum remains challenging, because numerous incongruent parcellation schemes for the primate claustrum exist. Here, we propose that evolutionarily conserved subdivisions of the claustrum complex can be identified across mammals by combining gene expression patterns, cytoarchitecture, and topological position. To this end, we compare selected claustrum-specific genes such as Nurr1, Oprk1, Lxn, and Cdh8 in several species including rats, Etruscan shrews, tree shrews, marmoset monkeys, and macaque monkeys to examine patterns of claustrum subdivision across these species.
Reference Key
openalex_W7164743877 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Chao Fang, Miao Li, Lanxiang Li, Feng Liang, J Huang, Li Lu, Zhonghua Lu, Hong Wang, Robert K. Naumann
Journal PNAS nexus
Year 2026
DOI
10.1093/pnasnexus/pgag214
URL
Keywords Keywords not found

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