Examining mechanisms by which acute psychosocial stress disrupts the proestrous LH surge and ovulation in female mice

Clicks: 1
ID: 317334
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal

Ranked #299 of 301 articles by views in american journal of physiology endocrinology and metabolism

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 301 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Stress most often inhibits reproduction. Exposure to an acute layered psychosocial stress paradigm (ALPS) on proestrus disrupts the LH surge in 60-70% of adult female mice without interfering with the progression of the estrous cycle. The present studies aimed to expand upon these observations by investigating effects of ALPS exposure on ovulation and potential mechanisms involved in surge disruption. The most common response to ALPS exposure was disruption of the LH surge and blockade of ovulation; however, in some mice in which no LH surge was detected, ovulation did occur. Factors from the adrenal cortex and medulla, corticosterone and catecholamines (norepinephrine and epinephrine), respectively, are increased during stress; we thus tested if these factors mediate the effects of stress on the LH surge and ovulation by applying ALPS in adrenalectomized (ADX) animals. ADX did not reverse the disruptions of the LH surge/ovulation after ALPS. Further studies aimed to investigate potential roles of individual adrenal factors in this response. We tested if administering corticosterone, in the absence of stress, was sufficient to suppress the LH surge and ovulation. It was not. Finally, we tested if blockade of β-adrenergic signaling during ALPS would rescue the LH surge and/or ovulation. Propranolol, a non-selective β-adrenergic receptor blocker, given one hour before ALPS failed to reverse the disruptive effects of stress. Together these data confirm the effectiveness of ALPS in disrupting both the LH surge and ovulation. They further indicate that the adrenal gland is dispensable for these effects.
Reference Key
openalex_W7164805920 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Elizabeth R. Wagenmaker, Amanda G. Gibson, Megan S. Johnson, Abira Afzal Choudhry, Nicholas M Provenzano, Bo Dong, Suzanne M. Moenter
Journal american journal of physiology endocrinology and metabolism
Year 2026
DOI
10.1210/endocr/bqag070
URL
https://doi.org/10.1210/endocr/bqag070
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.