Global source-sink dynamics of dengue viruses and epidemic establishment in areas on the fringe of endemic transmission

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ID: 317278
2026
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Abstract
Abstract The global expansion of dengue virus (DENV) poses a major public health threat, yet its circulation dynamics remain poorly understood. By integrating global genetic, epidemiological, and mobility data within a phylodynamic framework, we show that DENV circulation follows a source-sink model, with tropical endemic regions acting as persistent viral reservoirs (‘sources’) that seed epidemics in temperate areas (‘sinks’). Most areas at the fringe of endemic transmission exhibit sink-like characteristics with exception of South China. We identity a low-intensity dispersal route from South China to endemic Asia compared with the high-intensity source-to-sink direction, along with occasional DENV1 overwintering events in South China. Together, these findings suggest that South China occupies an intermediate state between endemic and non-endemic areas. These global DENV pathways were primarily driven by air travel and were reshaped by COVID-19 pandemic-related perturbations. Our findings highlight that dengue circulates within a fully interconnected global system that requires a shift from localized control to globally coordinated intervention efforts, as well as emphasize the importance of year-round genomic surveillance at the human-vector interface in fringe areas.
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openalex_W7164845189 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Z Chen, Marta Giovanetti, Zachary J. Madewell, Andi Sun, Weiwei Li, Chunmin Li, Haoyin Yu, Jimin Sun, Liyun Jiang, Pengzhe Qin, X W Wu, Marco Ajelli, Hongjie Yu
Journal national science review
Year 2026
DOI
10.1093/nsr/nwag372
URL
https://doi.org/10.1093/nsr/nwag372
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