Comment on ‘Context, not class, may be the key signal in systemic JAK inhibitor exposure in MF/SS’: reply from authors

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ID: 317217
2026
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Abstract
The effects of systemic JAKis exposure in MF/SS appear context dependent and should not be interpreted as a homogeneous entity. Although disease worsening was observed in several patients initially diagnosed with presumed inflammatory dermatoses, causality cannot necessarily be inferred and may reflect, among other factors, underlying MF/SS biology, referral bias, or concurrent immunosuppressive influences. In post-transplant MF/SS patients receiving JAKis for graft-versus-host disease, MF/SS progression may reflect impaired immune surveillance or other disease-related factors rather than a direct effect of JAKis. These findings underscore the complexity of interpreting JAKi exposure in MF/SS and highlight the need for prospective studies to better define risks across clinical settings.
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Authors Iris Amitay‐Laish, Keila Mitsunaga, P Ortiz-Romero, A de Masson, Erika Morsia, José Antônio Sanches, Paula Enz, Vasiliki Nikolaou, Constanze Jonak, Stefanie Porkert, Yael A. Leshem, Emily Avitan‐Hersh, Emmilia Hodak
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Journal the british journal of dermatology
Year 2026
DOI
10.1093/bjd/ljag240
URL
https://doi.org/10.1093/bjd/ljag240
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