Hot-water extract of defatted Perilla frutescens seed residue suppresses osteoclast differentiation and improves bone-related parameters in ovariectomized mice
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ID: 317176
2026
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Abstract
Abstract The defatted residue of Perilla frutescens seeds, a by-product of edible oil production, remains largely underutilized in food applications. This study investigated the effects of a hot-water extract derived from this residue on osteoclast differentiation and bone-related changes. In bone marrow-derived macrophages, the extract inhibited receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation, as evidenced by the reduced formation of tartrate-resistant acid phosphatase-positive multinucleated cells and decreased tartrate-resistant acid phosphatase activity, without significantly affecting cell viability. In ovariectomized mice, the extract increased trabecular region length and cortical bone thickness. In a separate experiment, it enhanced femoral mechanical strength in a three-point bending test. High-performance liquid chromatography analysis identified rosmarinic acid and salviaflaside in the extract. These findings suggest that defatted Perilla frutescens seed residue may be a functional resource for improving bone health.
| Reference Key |
openalex_W7164567510
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|---|---|
| Authors | Hiroyuki Asano, Sogo Nishimoto |
| Journal | bioscience biotechnology and biochemistry |
| Year | 2026 |
| DOI |
10.1093/bbb/zbag082
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| URL | |
| Keywords | Keywords not found |
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