Association between biologic exposure and relapse incidence in relapsing polychondritis: a retrospective cohort study
Clicks: 1
ID: 317147
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
0.0
/100
1 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
Ranked #148 of 202 articles by views in Lara D. Veeken
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 202 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
OBJECTIVES: Relapsing polychondritis (RP) is characterised by recurrent flares, and comparative evidence for relapse prevention using biologics remains limited. We evaluated the association between biologic exposure and relapse incidence. METHODS: This single-centre retrospective cohort study (Kyoto University Hospital, 2000-2023) investigated adults with RP. Follow-up was divided into periods without biologics (No Bio), with TNF-α inhibitors (TNFi), or with IL-6 receptor inhibitor (IL-6Ri). Primary outcomes were RP relapse and hospitalised infection. Period-level incidence rate ratios were estimated using negative binomial regression with a log(person-time) offset and adjusted for prespecified covariates, and adjusted absolute event rates and rate differences were estimated by regression standardisation. RESULTS: Over 503.5 person-years, 55 patients were included (never-Bio, n = 28; ever-Bio, n = 27). Within the ever-Bio cohort, crude relapse rates were 46.9, 22.4, and 12.5 per 100 person-years during the No Bio, TNFi, and IL-6Ri periods, respectively. In adjusted models, both TNFi and IL-6Ri were associated with lower relapse rates than the No Bio period (TNFi: IRR 0.4, 95% CI 0.2-0.8; adjusted rate difference, -54.0 events per 100 person-years, 95% CI -141.5 to -5.5; IL-6Ri: IRR 0.2, 95% CI 0.1-0.4; adjusted rate difference, -68.3 events per 100 person-years, 95% CI -149.8 to -21.4). Hospitalised infection estimates were imprecise (TNFi: IRR 0.3, 95% CI 0.1-1.4; IL-6Ri: IRR 0.7, 95% CI 0.2-2.6). CONCLUSION: Biologic exposure was associated with lower relapse rates than during No Bio periods in RP, whereas estimates for hospitalised infection were imprecise.
| Reference Key |
openalex_W7164556469
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Yoichi Nakayama, Yuki Aitani, Mirei Shirakashi, Toshiki Nakajima, Tsuneyasu Yoshida, Nozomi Nishimura, Tsuneo Sasai, Ryosuke Hiwa, Hideaki Tsuji, Shuji Akizuki, Kosaku Murakami, Ran Nakashima, Akio Morinobu, Hajime Yoshifuji |
| Journal | Lara D. Veeken |
| Year | 2026 |
| DOI |
10.1093/rheumatology/keag305
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.