Unimolecular dual-reporter probes for early kidney injury diagnosis through synchronous in situ imaging and portable urinalysis

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ID: 317136
2026
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Abstract
Abstract Early detection of acute kidney injury (AKI) is critical for effective intervention and improved survival, yet it remains challenging due to the lack of practical tools that sensitively capture subtle renal dysfunction. Here, we report a unimolecular dual-reporter probe, DHU-AKI-3, featuring activatable crosstalk-free multiplexed signal output for precise diagnosis of early AKI by integrating in situ imaging and in vitro portable urinalysis. Following systemic administration, DHU-AKI-3 is selectively activated in the injured kidney, producing a long-retained photoacoustic signal for real-time in situ imaging ahead of the clinical diagnostic window. Concurrently, a near-infrared fluorescent signal is rapidly released and excreted into urine, enabling smartphone-assisted colorimetric analysis for noninvasive, point-of-care testing. The mutual validation of crosstalk-free in situ and in vitro signals guaranteed the diagnostic accuracy. This study underscores the potential of unimolecular dual-reporter probe for directly visualizing early-stage AKI in urine, meeting the pressing demand for point-of-care testing in AKI management.
Reference Key
openalex_W7164562213 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Lingyan Liu, Feiyang Liu, Qihang Ding, S Y Wang, Peng Wei, Jong Seung Kim, Tao Yi
Journal national science review
Year 2026
DOI
10.1093/nsr/nwag367
URL
https://doi.org/10.1093/nsr/nwag367
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