Delta-9-tetrahydrocannabutol (Δ9-THCB), Delta-9-tetrahydrocannabihexol (Δ9-THCH), and Delta-9-tetrahydrocannabiphorol (Δ9-THCP): the Impact of Varying Alkyl Chain Length on Delta-9-tetrahydrocannabinol (Δ9-THC) Analog Metabolism

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ID: 317117
2026
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Abstract
Abstract Increasing availability of delta-9-tetrahydrocannabinol (Δ9-THC) analogs including Δ9-tetrahydrocannabutol (Δ9-THCB), Δ9-tetrahydrocannabihexol (Δ9-THCH), and Δ9-tetrahydrocannabiphorol (Δ9-THCP) in unregulated products has raised questions about the impact of alkyl sidechain length not only on potency, but on metabolism. Δ9-THC homologs were metabolized in vitro with human liver microsomes, and multiple time points were collected. Multiple reaction monitoring (MRM) and precursor ion (PI) scanning methods presumptively identified that Δ9-THCB, Δ9-THCH, and Δ9-THCP produced hydroxylated and carboxylated phase I biomarkers, similar to those of Δ9-THC. The use of universal product ions containing a common core highlights their potential to assist laboratories in future identification of novel Δ9-THC analogs. One carbon deviation in alkyl sidechain length resulted in a decreased formation of the hydroxylated biomarker; whereas two carbon deviations further decreased the amount produced. Although the metabolism rate of the hydroxylated biomarkers was reduced, any deviation from the five-carbon sidechain increased the conversion from the hydroxylated biomarker to the carboxylated biomarker by the cytochrome P450 enzymes. Presumptive identification of novel THC analog metabolites provides new analytical targets for toxicology laboratories seeking the causative agent(s) in cases of suspected intoxication and/or drug toxicity. By understanding the metabolism of novel THC analogs, critical information can then be provided to the public regarding the potential risks of these mass-produced products.
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openalex_W7164533938 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors K. James, Justin L. Poklis, Erin L Karschner, Sara K. Dempsey, Michelle R. Peace
Journal journal of analytical toxicology
Year 2026
DOI
10.1093/jat/bkag045
URL
https://doi.org/10.1093/jat/bkag045
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