Corticostriatal connectivity in monozygotic twin pairs discordant for obsessive-compulsive disorder
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ID: 316925
2026
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Abstract
Traditional case-control studies show that obsessive-compulsive disorder (OCD) is associated with disturbances in cortico-striatal-thalamo-cortical (CSTC) brain circuits. Whether these findings represent underlying familial vulnerabilities (i.e., shared genetic and environmental factors) or are the result of acquired non-shared environmental influences, such as chronic stress or lifestyle factors, is unknown. Using a unique sample of monozygotic twin pairs discordant for lifetime OCD diagnoses (14 pairs, 28 twins) and resting-state functional magnetic resonance imaging, we examined the contribution of non-shared environmental influences to CSTC functional connectivity while strictly controlling for shared genetic and environmental factors. Further, we examined familial vulnerability effects by comparing the unaffected co-twins of OCD-affected twins to a sample of control twins (14 pairs, 28 twins). Non-shared environmental influences were statistically significantly associated with thalamostriatal hypoconnectivity, whereas familial vulnerability was significantly associated with heightened connectivity between the striatum and the medial orbitofrontal cortex. These findings suggest that non-shared environmental and familial factors may differentially relate to distinct CSTC circuit disturbances in OCD.
| Reference Key |
openalex_W7164125437
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| Authors | Jan C. Beucke, Lennart May, Ibai Diez, Julia Franke, Christian Kaufmann, Josep Pol-Fuster, Lorena Fernández de la Cruz, Elles de Schipper, Gustaf Brander, Karl Lundin Remnélius, Janina Neufeld, Peter Fransson, Jorge Sepulcre, Odile A Van den Heuvel, Sven Bölte, David Mataix-Cols |
| Journal | Brain research |
| Year | 2026 |
| DOI |
10.1093/brain/awag198
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| URL | |
| Keywords | Keywords not found |
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