Treatments for Pediatric Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Critical Appraisal and Systematic Review

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ID: 316877
2026
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Abstract
Although Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are rare, their impact on children is disproportionately severe, with recent US data suggesting a rising incidence of 0.5–6.3 cases per 100,000 children annually. Pediatric SJS/TEN is characterized by substantial mortality, long-term physical and psychological sequelae, and frequent overlap features that complicate diagnosis. Despite this, pediatric-specific evidence is scarce. Ethical constraints preclude randomized controlled trials (RCTs), leaving clinicians without consensus guidelines on systemic therapies. To address this gap, we systematically reviewed real-world treatment approaches and outcomes in pediatric SJS/TEN.
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openalex_W7164184828 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yu‐Chieh Chiu, Sheng-Hsiang Ma, Tai‐Li Chen
Journal the british journal of dermatology
Year 2026
DOI
10.1093/bjd/ljag237
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