From gatekeeper to target: MAPK cascades as control circuits at the insect-microbe interface
Clicks: 4
ID: 316870
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
0.9
/100
4 views
2 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #65 of 100 articles by views in FEMS microbiology reviews
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Abstract Mitogen-activated protein kinase (MAPK) signaling cascades are conserved modules that orchestrate multiple processes, including immunity, stress adaptation, and tissue homeostasis. In insects, MAPK pathways function as central regulatory circuits, coordinating defense responses and resistance mechanisms against diverse pathogens. MAPK cascades couple damage sensing in the gut epithelium to intestinal regeneration, pathogen/microbiota stability, cellular and humoral immune responses, and immune homeostasis. Consequently, a wide range of pathogens (parasites, viruses, and bacteria) target, suppress, or hijack key regulatory bottlenecks MAPK networks to promote pathogen invasion, replication or transmission. Understanding this molecular arms race provides insight into fundamental principles governing insect-microbe coevolution and reveals critical regulatory nodes that could be exploited to develop innovative strategies for controlling insect pests and vector-borne diseases.
| Reference Key |
openalex_W7164206535
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Shi Kang, Yang Bai, Neil Crickmore, Mário Soberón, Xuguo Zhou, Youjun Zhang, Alejandra Bravo, Zhaojiang Guo |
| Journal | FEMS microbiology reviews |
| Year | 2026 |
| DOI |
10.1093/femsre/fuag027
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.