BRAF-altered glioma in adults and children: A Society for Neuro-Oncology (SNO) and European Society for Neuro-Oncology (EANO) consensus review on clinical management and future directions

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ID: 316561
2026
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Abstract
Oncogenic BRAF alterations occur in a subset of diffuse gliomas across WHO grades and are increasingly identified through modern molecular diagnostics. In addition to standard glioma therapies, targeted treatments are available for patients with BRAF-altered glioma supported by variable evidence spanning randomized trials, single-arm studies, and real-world evidence. This joint consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO) synthesizes current knowledge on the diagnosis and management of BRAF-altered gliomas across age groups, tumor grades, and lines of therapy. Particular emphasis is placed on expert consensus in clinical scenarios where high-quality trial evidence remains limited. The review addresses rationale testing for BRAF alterations, selection, and monitoring of targeted therapies, management of treatment-related toxicities, approaches to resistance, and priorities for future research. It aims to provide practical, evidence-based guidance for clinicians while highlighting gaps to inform prospective studies.
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openalex_W7164046208 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Karisa C Schreck, Macarena I de la Fuente, Mary Jane Lim Fat, S L Maas, Jean M Mulcahy Levy, G Lombardi, Sébastien Perrault, Claudia Petritsch, Kenneth Aldape, Susan M Chang, Johnny Duerinck, Matthias Holdhoff, Tomas Kazda, Emilie Le Rhun, Giuseppe Minniti, Mark V. Mishra, Sabine Mueller, Marta Padovan, M Preusser, Marion Smits, Michael Weller, Patrick Y Wen, Martin van den Bent, Marjolein Geurts
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Journal journal of neuro-oncology
Year 2026
DOI
10.1093/neuonc/noag135
URL
https://doi.org/10.1093/neuonc/noag135
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