β-Catenin Does Not Co-activate Vitamin D Receptor–mediated Transcription in Osteoblastic and Non-osteoblastic Cells
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ID: 316456
2026
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Abstract
Abstract Vitamin D (VD) and Wnt signaling both play important roles in bone metabolism and are targeted in osteoporosis therapy. Combination treatment with VD derivatives and anti-sclerostin antibodies that activate Wnt signaling improves clinical outcomes, although the molecular basis of this cooperative effect remains unclear. Because β-catenin functions as a transcriptional co-regulator in canonical Wnt signaling, we examined whether β-catenin modulates vitamin D receptor (VDR)–mediated transcription. Reporter assays were performed in Saos-2 osteoblastic cells using vitamin D response element (VDRE) and TCF/LEF-responsive reporters. Activation of Wnt signaling by CHIR99021 or expression of constitutively active β-catenin did not enhance VDR transcriptional activity but modestly suppressed VD-induced transcription. Similar results were obtained in HCT116 and COS-1 cells. These findings indicate that VDR and Wnt/β-catenin signalings are not cross-talked at the transcriptional level.
| Reference Key |
openalex_W7164049515
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| Authors | Tram Thi-Ngoc Nguyen, Yoshiaki Kanemoto, Takahiro Sawada, Jingyun Zhang, Tomohiro Kurokawa, Shigeaki Kato |
| Journal | bioscience biotechnology and biochemistry |
| Year | 2026 |
| DOI |
10.1093/bbb/zbag084
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| URL | |
| Keywords | Keywords not found |
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