DNAviWEB: sequencing-free clinical screening of liquid biopsies

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ID: 316429
2026
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Abstract
Noninvasive cell-free DNA (cfDNA) fragmentation profiles are gaining popularity as diagnostic tools for a wide range of conditions contributing to the global health burden, such as cancer, autoinflammatory disorders, and adverse events in pregnancy or transplantation. Despite their diagnostic value, fragmentomics rely on DNA sequencing, resulting in significant costs and turnaround times, therefore limiting their translation to everyday clinical care. Here, we present DNAviWEB (https://dnavi.sc.hpi.de/), a freely accessible implementation of the DNAvi analysis tool for exploring cfDNA fragmentomics from DNA gel electrophoresis in research settings. DNAviWEB enables instant presequencing analysis of cfDNA while integrating into medical workflows by providing browsable European Genome-phenome Archive and European Liquid Biopsy Society metadata catalogs and delivering rich outputs of patient group-stratified cfDNA statistics, visualizations, and secure storage capacities for clinical data. The DNAviWEB platform opens the exploration, analysis, and database deposition of liquid biopsy DNA profiles to a broad community of clinicians and researchers. DNAviWEB is free and open source.
Reference Key
openalex_W7163906410 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Anja Hess, Yara Matani, Dominik Seelow, Helene Kretzmer
Journal Nucleic Acids Research
Year 2026
DOI
10.1093/nar/gkag446
URL
https://doi.org/10.1093/nar/gkag446
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