Zoster Vaccination and Dementia: Interpreting the Signal and Testing the Mechanisms

Clicks: 2
ID: 316413
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #409 of 531 articles by views in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 531 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Several observational studies and recent natural experiments suggest that herpes zoster vaccination is associated with fewer subsequent dementia diagnoses. Quasi-experimental analyses that exploit date-of-birth eligibility thresholds, largely involving the live attenuated zoster vaccine, strengthen causal inference by reducing confounding from preventive-care behaviors and healthcare utilization; however, they do not establish mechanism or distinguish disease prevention from delayed diagnosis. Three non-mutually exclusive pathways merit direct evaluation: reduced cumulative varicella-zoster virus reactivation burden, including recurrent and possibly unrecognized events; vaccine-induced immune modulation that alters immune aging and inflammatory responses; and neurovascular and neuroinflammatory injury as intermediate pathways linking zoster to later cognitive decline. Priority should now shift to stronger causal designs, pathway-focused analyses of reactivation and vascular intermediates, and prospective studies incorporating longitudinal immune phenotyping and blood-based biomarkers.
Reference Key
openalex_W7163924162 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Nadine Rouphael
Journal Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Year 2026
DOI
10.1093/cid/ciag358
URL
https://doi.org/10.1093/cid/ciag358
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.