Solvent- and Catalyst-Free Direct Conversion of Malonic Esters to Carboxylic Acids via Thermal Cleavage of tert -Butyl Ester and Decarboxylation

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ID: 316357
2026
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Abstract
Abstract A solvent- and catalyst-free method for the direct conversion of malonic esters to carboxylic acids has been developed via thermal cleavage of tert-butyl esters followed by decarboxylation. The protocol avoids hydrolysis and proceeds rapidly at 400 °C (2 min) under neat conditions, providing efficient access to carboxylic acids from relatively simple substrates. Although the elevated temperature may limit functional group compatibility, several groups are tolerated.
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Authors Shingo Ishikawa, Yuto Tanaka, Nayu Kodama, Tetsuo Nishimata, Kazuki Miyamoto, Keigo Fugami
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Journal phytochemistry letters
Year 2026
DOI
10.1093/chemle/upag111
URL
https://doi.org/10.1093/chemle/upag111
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