Change in body mass index and physical activity and postmenopausal breast cancer risk in a cohort of Dutch nurses

Clicks: 1
ID: 316133
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal

Ranked #304 of 332 articles by views in JNCI Journal of the National Cancer Institute

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 332 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
BACKGROUND: Body mass index and physical activity are among the best established risk factors for breast cancer (BC). We examined changes in these factors and postmenopausal BC risk in a cohort of registered Dutch female nurses. METHODS: Participants completed a questionnaire at enrollment and up to two follow-up questionnaires. Body mass index (BMI, in kg/m2) and physical activity were assessed at age 18, at enrollment and prospectively around menopause. Associations with postmenopausal BC risk were assessed using multivariable Cox models. RESULTS: With a median follow-up of 13.2 years, 1,776 incident breast cancers occurred among 43,127 postmenopausal women. A BMI ≥25 at menopause was associated with increased BC risk. A high level of sports activity was associated with decreased BC risk (ptrend 0.04) only among overweight (BMI = ≥25 to 30) women. The Hazard Ratio (HR) for postmenopausal BC increased 1.06-fold (95% Confidence Interval (CI)=1.04-1.09) with every 5kg weight gain between age 18 and menopause. Physical activity did not modify this association. Women with normal weight at enrollment, who developed overweight/obesity, had increased risk of postmenopausal BC (HR = 1.39, 95% CI = 1.06-1.83). We observed no clear associations between changes in physical activity since enrollment and BC risk, irrespective of BMI changes. CONCLUSIONS: Weight gain between age 18 and menopause is associated with increased postmenopausal BC risk, irrespective of physical activity. Being overweight/obese and developing overweight/obesity at menopause increases postmenopausal BC risk, however higher sports activity at the time of enrollment may be associated with a lower BC risk among overweight women.
Reference Key
openalex_W7163747624 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Henriëtte M. van Duijne, Nina E. Berentzen, Roel CH Vermeulen, Jelle J Vlaanderen, Hans Kromhout, Katarzyna Jóźwiak, Matti Rookus, Flora E van Leeuwen, Michael Schaapveld
Journal JNCI Journal of the National Cancer Institute
Year 2026
DOI
10.1093/jnci/djag177
URL
https://doi.org/10.1093/jnci/djag177
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.