Primary Graft Dysfunction and Baseline Lung Allograft Dysfunction: Risk Factors and Associations With Outcomes After Lung Transplantation

Clicks: 1
ID: 315733
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal

Ranked #426 of 432 articles by views in the british journal of surgery

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 432 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Background Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation (LTx). Baseline lung allograft dysfunction (BLAD), indicating impaired graft function one year after LTx, is less well characterized, and its relationship with PGD remains uncertain. Aims We aimed to identify risk factors for PGD and assess its association with BLAD and outcomes. Methods All LTx recipients at Lausanne University Hospital (2008–2021) were retrospectively analyzed. Multivariate logistic regression identified risk factors for PGD and its association with BLAD and survival. Results Among 276 patients, 65 (23.6 %) developed PGD III. Independent predictors were younger age (OR 0.98/y, p = 0.025), female sex (OR 2.45, p = 0.003), lower donor PaO₂/FiO₂ (OR 0.99 per 10 mmHg, p = 0.02), and higher transfusions (OR 3.3, p < 0.01). PGD III was associated with prolonged ventilation (57 % vs 15 %, p < 0.01), reoperation (32 % vs 13 %, p < 0.01), longer ICU (22 vs 5 days, p < 0.001), and hospital stay (38 vs 24 days, p < 0.001). BLAD occurred more often in PGD III (59 % vs 38 %, OR 2.4, p = 0.009) and in patients transplanted for fibrotic lung disease (36 % vs 9 %, OR 5.8, p < 0.001). BLAD correlated with higher transfusions, reoperation, and prolonged ventilation. Survival did not differ between PGD III and non-PGD (1-, 3-, 5-y: 83.5 %, 74.2 %, 66.0 % vs 95.7 %, 87.1 %, 79.0 %; p = 0.53) nor between BLAD and non-BLAD. Conclusion PGD III after LTx is associated with increased perioperative morbidity and a higher risk of BLAD. Both conditions correlate with transfusion requirements and ventilatory complications, emphasizing the need for targeted perioperative strategies to improve graft recovery and long-term function.
Reference Key
openalex_W7163424371 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors A Hasenauer, C Soldini, E Abdelnour-Berchtold, Z Balmpouzis, R Troxler, T Schreder, K Jahn, G Berra, M Gonzalez, J Y Perentes, M Zellweger, L Liaudet, A Koutsokera, T Krueger
Journal the british journal of surgery
Year 2026
DOI
10.1093/bjs/znag055.056
URL
https://doi.org/10.1093/bjs/znag055.056
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.