Lipid Oxidation in Chronic Thromboembolic Pulmonary Hypertension: A Clue to Residual Pulmonary Hypertension After Surgery?
Clicks: 3
ID: 315711
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
0.6
/100
3 views
2 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #247 of 432 articles by views in the british journal of surgery
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 432 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Abstract Background Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by two distinct vascular lesions: proximal thromboembolic obstructions and secondary distal microvasculopathy. These lesions lead to elevated pulmonary vascular resistance (PVR > 2 Wood Units, WU), ultimately resulting in right heart failure and death if left untreated. Pulmonary endarterectomy is the guideline-recommended surgical intervention for obstructive lesions in operable patients. However, up to 50% of patients exhibit residual pulmonary hypertension after surgery, due to persistent microvascular lesions. Aims The aim of this project was to identify molecular pathways in pre-operative plasma samples associated with non-response to surgery, in order to explore potential predictive biomarkers and therapeutic targets for microvasculopathy. Methods We included 34 patients who met the following criteria: availability of pre-operative plasma samples, underwent pulmonary endarterectomy, and had a right heart catheterization at the one-year follow-up visit. A plasma proteomic analysis was performed on these pre-operative samples. Patients were classified as Responders (PVR ≤ 2 WU at one-year post-surgery) or Non-Responders (PVR > 2 WU). Results Responders and Non-Responders exhibited comparable pre-operative hemodynamic parameters. Proteomic analysis of pre-operative plasma samples revealed distinct molecular profiles between the two groups. Enrichment analysis of differentially expressed proteins identified dysregulated pathways related to lipid transport and remodeling in Non-Responders. Pre-operative circulating lipid analysis showed comparable total cholesterol, LDL, HDL, and triglyceride levels between the two groups. However, pre-operative circulating oxidized LDL levels were significantly higher in Non-Responders, whereas plasma total antioxidant capacity was significantly lower. Conclusion Our findings suggest that lipid remodeling, and in particular elevated pre-operative circulating oxidized LDL, is associated with non-response and residual pulmonary hypertension after surgery. Further studies are required to clarify the contribution of elevated oxidized LDL to the development of microvasculopathy in CTEPH.
| Reference Key |
openalex_W7163374485
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | F Robert, B Bianca, U Maheshwari, T Scheithauer, K Chiffi, A Tönz, M Ronner, S Arni, T Kockmann, P Nanni, V Boeva, M Meerang, I Opitz |
| Journal | the british journal of surgery |
| Year | 2026 |
| DOI |
10.1093/bjs/znag055.072
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.