Variability in Breath Alcohol Concentration Profiles During Controlled Social Drinking

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ID: 315617
2026
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Abstract
Abstract Controlled alcohol studies often use standardized dosing conditions to characterize absorption and elimination. The present study evaluated breath alcohol concentration (BrAC) profiles under supervised social drinking conditions that permitted variability in beverage consumption and food intake. Forty-two adult participants consumed self-selected 80-proof mixed drinks with ad libitum access to food. Drinking duration ranged from 45 to 172 minutes (mean 108 minutes, median 110 minutes), reflecting substantial variability in consumption time across participants. BrAC was measured at approximately 30-minute intervals using an Intox EC/IR II until return to zero. Peak BrAC ranged from 0.040 to 0.117 g/210 L (mean 0.087). Time from the final drink to peak ranged from −23 to 76 minutes (mean 17 minutes, median 13 minutes). The mean elimination rate was 0.0186 g/210 L/hr (SD 0.0027, range 0.0134 to 0.0261). Most participants reached peak concentration shortly after drinking ceased, although delayed peaks of more than one hour were observed in some individuals. Representative curves demonstrated variability in absorption timing, including occasional multi-peak profiles, while post-peak elimination was generally linear. These findings characterize the range of BrAC–time patterns observed under supervised social drinking conditions and provide context for interpreting alcohol measurements in applied settings.
Reference Key
openalex_W7163337189 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ryan S. O’Connor, Jennifer Wang, Jay R Vargas
Journal journal of analytical toxicology
Year 2026
DOI
10.1093/jat/bkag038
URL
https://doi.org/10.1093/jat/bkag038
Keywords Keywords not found

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