Monoclonal gammopathy of undetermined significance is not associated with increased risk of skin cancer

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ID: 315565
2026
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Abstract
Multiple myeloma is a known risk factor for skin cancer. However, the impact of its precursor, monoclonal gammopathy of undetermined significance (MGUS), on this risk is unknown. Our objectives were to characterize the relationship of MGUS with the frequency and relative survival of skin cancer. Data for this study were acquired from the iStopMM study, a nationwide screening study for MGUS; and the Icelandic Cancer Registry, a national database that records all histologically confirmed skin cancers diagnosed in Iceland. A multivariable regression analysis adjusting for age and sex did not identify a difference in the frequency of skin cancer, and survival analyses did not identify a difference between groups. Although MGUS is the precursor condition for multiple myeloma, we did not identify an association between MGUS and skin cancer.
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Authors Jónas A. Aðalsteinsson, Gauti Kjartan Gislasson, Styrmir Hallsson, Kelley Sharp, Sigrún Thorsteinsdóttir, Sæmundur Rögnvaldsson, Ásdís Rósa Þórðardóttir, Brynjar Viðarsson, Páll T. Önundarson, Bjarni A. Agnarsson, Margrét Sigurðardóttir, Ingunn Þorsteinsdóttir, Ísleifur Ólafsson, Elias Eythorsson, Ásbjörn Jónsson, Andri Ólafsson, Jon Kristinn Sigurdsson, Jon Gunnlaugur Jonasson, Ola Landgren, Malin Hultcrantz, BG Durie, Stephen Harding, Þorvarður Jón Löve, Sigurdur Yngvi Kristinsson
Journal the british journal of dermatology
Year 2026
DOI
10.1093/bjd/ljag119
URL
https://doi.org/10.1093/bjd/ljag119
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