N-acetylcysteine exerts senescence-selective antifibrotic effects in fibroblast from chronic wounds in Recessive Dystrophic Epidermolysis Bullosa

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ID: 315558
2026
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Abstract
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe inherited skin disease caused by pathogenic biallelic variants in COL7A1, resulting in dermal-epidermal fragility and chronic, non-healing wounds1. We investigated the contribution of fibroblast senescence to RDEB wound pathology and evaluated whether NAC can modulate this process.
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openalex_W7163207863 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Evelyng Catalán, Belén Dianta, Nicole Koplow, Paola Tiozzo-Lyon, Gabriela Faune, Pilar Morandé, Francis Palisson, Catalina Soto-Montandon, A. Ravasio, Andrew P South, Boris Rebolledo-Jaramillo, Alexander Nyström, Ignacia Fuentes
Journal the british journal of dermatology
Year 2026
DOI
10.1093/bjd/ljag223
URL
https://doi.org/10.1093/bjd/ljag223
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