FcμR enhances recall responses by promoting the generation of CD80+PD-L2+ memory B cells
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ID: 315506
2026
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Abstract
The IgM Fc receptor (FcμR), the sole receptor specific for IgM, is crucial for B cell survival and humoral immunity. Yet, its role in memory B cells (MBCs) has remained unclear. Here, we show that FcμR-/- mice immunized with the T-dependent antigen 4-hydroxy-3-nitrophenyl acetyl-chicken γ-globulin (NP-CGG) generate normal numbers of IgG1+ MBCs with long-term survival comparable to that of WT mice. However, the IgG1+ MBCs in FcμR-/- mice contained a reduced proportion of mature CD80+PD-L2+ cells, a subset associated with potent recall responses and plasma cell differentiation. Consistently, adoptive transfer of NP-specific MBCs and CGG-specific memory T cells into Rag1-/- mice revealed significantly diminished memory B cell responses in recipients of FcμR-/- MBCs. Mechanistically, FcμR-/- IgG1+ MBCs exhibited impaired B cell receptor signaling and reduced activation of transcription factors essential for plasma cell differentiation upon antigen re-challenge both in vivo and in vitro. Together, these findings establish FcμR as a previously unrecognized key regulator of CD80+PD-L2+ MBC formation and recall responses.
| Reference Key |
openalex_W7163155407
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| Authors | Runyun Zhang, Jiping Sun, L L Dong, Ziying Hu, Qing Min, Ying Wang, Zichao Wen, Jingjing Zhao, Yì Wáng, Jun Liu, Xiaoqian Feng, Yingying Luan, Xin Meng, Meiping Yu, Yaxuan Li, Chaoqun Cui, Chunhui Lu, 吳徐哲, Koji Hase, Yoshimasa Takahashi, Tomohiro Kurosaki, Yì Wáng |
| Journal | international immunology |
| Year | 2026 |
| DOI |
10.1093/intimm/dxag028
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| URL | |
| Keywords | Keywords not found |
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