Chemical study, antioxidant, anti-hypertensive, and cytotoxic/cytoprotective activities of Centaurea cyanus L. petals aqueous extract.

Clicks: 246
ID: 3155
2018
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Ranked #29 of 54 articles by views in food and chemical toxicology : an international journal published for the british industrial biological research association

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Abstract
This study aimed to optimise the experimental conditions of extraction of the phytochemical compounds and functional properties of Centaurea cyanus petals. The following parameters were determined: the chemical composition (LC-ESI-MS/MS), the effects of pH on the stability and antioxidant activity of anthocyanins, the inhibition of lipid peroxidation, antioxidant activity, anti-hemolytic activity, antimicrobial, anti-hypertensive, and cytotoxic/cytoprotective effect, and the measurements of intracellular reactive oxygen species. Results showed that the temperature and time influenced (p ≤ 0.05) the content of flavonoids, anthocyanins, and FRAP. Only the temperature influenced the total phenolic content, non-anthocyanin flavonoids, and antioxidant activity (DPPH). The statistical approach made it possible to obtain the optimised experimental extraction conditions to increase the level of bioactive compounds. Chlorogenic, caffeic, ferulic, and p-coumaric acids, isoquercitrin, and coumarin were identified as the major compounds in the optimised extract. The optimised extract presented anti-hemolytic and anti-hypertensive activity in vitro, in addition to showing stability and reversibility of anthocyanins and antioxidant activity with pH variation. The C. cyanus petals aqueous extract exhibited high IC and GI (>900 μg/mL) values for all cell lines, meaning low cytotoxicity. Based on the stress oxidative assay, the extract exhibited pro-oxidant action (10-100 μg/mL) but did not cause damage or cell death.
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escher2018chemicalfood Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Escher, Graziela Bragueto;Santos, Jânio Sousa;Rosso, Neiva Deliberali;Marques, Mariza Boscacci;Azevedo, Luciana;do Carmo, Mariana Araújo Vieira;Daguer, Heitor;Molognoni, Luciano;Prado-Silva, Leonardo do;Sant'Ana, Anderson S;da Silva, Marcia Cristina;Granato, Daniel;
Journal food and chemical toxicology : an international journal published for the british industrial biological research association
Year 2018
DOI
S0278-6915(18)30346-6
URL
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