A transfer RNA inosine modification drives genome-wide synonymous recoding across human commensal bacterial families
Clicks: 9
ID: 315206
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
2.4
/100
9 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #13 of 88 articles by views in PNAS nexus
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Abstract Inosine modification on tRNA anticodon (I34) is universally conserved in three kingdoms of life and critical to tRNA decoding capabilities. We found that tRNALeu(IAG) in commensal human bacterial families in Lactobaccilalles is concurrent with genome-wide synonymous leucine codon reprogramming. Pathway analysis reveals significant synonymous Leu codon changes in proteins in multiple KEGG pathways on cellular metabolism, where many genome-wide dominant UUA in families without tRNALeu(IAG) is reprogrammed to CUU, CUC and UUG in families with tRNALeu(IAG). We provide biochemical and phenotypic results to support mechanisms that enable synonymous Leu codon substitutions to confer greater translation equivalency and growth fitness, indicating that a tRNA inosine modification can propel the genome-wide evolution of synonymous leucine codons.
| Reference Key |
openalex_W7162793954
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Christopher D. Katanski, Chathuri Pathirage, Jennifer C Chang, Iva Veseli, T.J. Smith, Marcus Foo, Yuan Wu, Yichen Hou, Hoang Anh V Tran, Dominika Rudzka, Wen Zhang, Mohammad Amin Bayat Tork, Karen Lolans, Amy D. Willis, Weixin Tang, A Murat Eren, Michael Federle, Kristin S. Koutmou, Tao Pan |
| Journal | PNAS nexus |
| Year | 2026 |
| DOI |
10.1093/pnasnexus/pgag187
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.