MRI-compatible soft fiber bioelectronics for multimodal assessment of electrical neural stimulation on whole-brain activation
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ID: 315145
2026
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Abstract
Abstract Deciphering mechanisms of electrical neural stimulation using multimodal approaches combining electrophysiology and magnetic resonance imaging (MRI) is pivotal for advancing neuromodulation therapies. However, this paradigm has been hindered by the lack of high-performance neural electrodes that are compatible with ultra-high-field MRI while possessing exceptional electrochemical properties. Here, we report an MRI-compatible fiber neural electrode (MFE) fabricated from structurally optimized conductive polymer fiber emulating brain tissue characteristics. The MFE induces little-to-no MRI artifacts at 11.7 T and combines low modulus, low impedance, and high charge-injection-limit, enabling precise neural stimulation and recording. Utilizing these MFEs, we investigated frequency-dependent whole-brain responses to electrical stimulation of the medial prefrontal cortex in wild-type and autism-model rats, revealing responses potentially relevant to autism intervention. This was achieved through electrical stimulation synchronized with electrophysiological recording and multimodal MRI, including functional MRI, diffusion-weighted imaging (tissue structural assessment), and magnetic resonance spectroscopy (metabolite profiling). Our MFE enables previously unattained simultaneous acquisition of multimodal information, providing a powerful tool for in-depth mechanistic studies of neuromodulation.
| Reference Key |
openalex_W7162641868
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| Authors | Wenjun Li, Li X, Haibo Yang, Chengqiang Tang, Zi Wang, Q Wang, Yingnan Nie, Liu Z, Yiqing Yang, He Wang, Songlin Zhang, Xiao‐Yong Zhang, Shouyan Wang, Huisheng Peng, Xuemei Sun |
| Journal | national science review |
| Year | 2026 |
| DOI |
10.1093/nsr/nwag325
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| URL | |
| Keywords | Keywords not found |
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