Targeting Porphyromonas gingivalis virulence and viability with epimedokoreanin B prevents alveolar bone destruction in vivo

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ID: 315076
2026
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Abstract
Abstract Periodontal disease is a major oral infectious condition that leads to the degradation of alveolar bone and subsequent tooth loss. Porphyromonas gingivalis, a keystone pathogen in periodontitis, plays a critical role in disease initiation and progression. In a previous study, we demonstrated the anti-P. gingivalis activity of epimedokoreanin B, a prenylated flavonoid derived from Epimedium species. However, its in vivo efficacy against periodontitis remains unclear. Oral administration of epimedokoreanin B attenuated P. gingivalis-induced alveolar bone resorption in murine periodontitis models and suppressed infection-induced antibody production Furthermore, epimedokoreanin B compromised bacterial membrane integrity and virulent gene expressions. In this preclinical study, in vitro and in vivo analyses indicate that epimedokoreanin B suppressed both bacterial viability and virulence, thereby attenuating alveolar bone loss caused by periodontitis. These findings suggest that epimedokoreanin B is a promising candidate for the development of novel therapeutics targeting periodontal pathogens.
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Authors Toru Kariu, Keisuke Nakashima, Tsuyoshi Ikeda
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Journal bioscience biotechnology and biochemistry
Year 2026
DOI
10.1093/bbb/zbag075
URL
https://doi.org/10.1093/bbb/zbag075
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