Detection of Merkel cell polyomavirus large T-antigen in Spitz naevi: a multimodal study
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ID: 315074
2026
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Abstract
This study provides the first documentation of Merkel cell polyomavirus (MCPyV) T-antigen expression in Spitz naevi, with 41.1% immunohistochemical positivity (58/141), 20.0% qPCR positivity (11/55), and electron microscopy confirmation in 75% (3/4) of examined cases. The detection pattern (IHC>PCR) indicates transcriptionally-active viral infection rather than passive colonisation, expanding MCPyV cellular tropism beyond neuroendocrine lineage to melanocytic cells. These findings represent a paradigm shift in viral oncology with potential implications for biomarker development in diagnostically-challenging spitzoid lesions.
| Reference Key |
openalex_W7162562260
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| Authors | Murilo Carapeba, Caroline Pereira, Fernanda Pereira, Alexandre Michalany, Emily Pilar, Aline Talarico, Anna da Silva, Camila Ferreira, Isabelle de Oliveira, Julio De Moraes, Felipe Saueiro, Rute Lellis, Trace Christensen, Isabel Gomes, Gabriel Cohlmia, Sofia Olsson, Amaro Duarte Neto, Leonardo de Araujo, A Dacosta |
| Journal | the british journal of dermatology |
| Year | 2026 |
| DOI |
10.1093/bjd/ljag220
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| URL | |
| Keywords | Keywords not found |
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